8/11/2023 0 Comments Nanoscope analysis bruker download![]() Ca 2+ serves as an essential second messenger in T cells to regulate their activation, proliferation, and effector functions ( Trebak and Kinet, 2019). Upon T cell activation, intracellular Ca 2+ concentration is drastically enhanced via Ca 2+ influx. During IS formation, the adhesion molecule LFA-1 (lymphocyte function-associated antigen 1) binds its ligand ICAM1 (Intercellular Adhesion Molecule 1) on the target cells to seal and stabilize the IS ( Bromley et al., 2001). Consequently, CD3 molecules, one key component of the TCR complex, transduce the signal to activate downstream pathways leading to formation of a tight contact between T cells and target cells termed the immunological synapse (IS) ( Bromley et al., 2001). T cells are activated by the engagement of T-cell receptors (TCRs) with the matching antigen on the target cells.
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